The term Primordial Dwarfism covers a number of different conditions (MOPD type I, II & III; Seckel Syndrome, Russell-Silver Syndrome, Meyer-Gorlin Syndrome). Growth is proportionate, but severely delayed. In January 2008, it was published in the academic journal Science, that mutations in the pericentrin gene were found to cause primordial dwarfism. Pericentrin has a role in cell division, proper chromosome segregation, and cytokinesis.Primordial dwarfism is very rare and there are currently estimated to be a few hundred individuals with this condition worldwide.

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